Structure of E. coli GlpG in complex with peptide derived inhibitor Ac-VRHA-conh-[4-(4-butyl)-phenoxy-1-phenyl-2-butyl]

Structure of E. coli GlpG in complex with peptide derived inhibitor Ac-VRHA-conh-[4-(4-butyl)-phenoxy-1-phenyl-2-butyl] Descriptor: Ac-VRHA-conh-[4-(4-butyl)-phenoxy-1-phenyl-2-butyl], Rhomboid protease GlpG Authors: Skerlova, J, Polovinkin, V, Bach, K, Borshchevskiy, V, Strisovsky, K. Deposit date: 2022-07-04 Release date: 2023-10-25 Last modified: 2026-03-04 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Extensive targeting of chemical space at the prime side of ketoamide inhibitors of rhomboid proteases by branched substituents empowers their selectivity and potency. Eur.J.Med.Chem., 275, 2024大肠杆菌GlpG与肽源抑制剂Ac-VRHA-conh-[4-(4-丁基)-苯氧基-1-苯基-2-丁基]的复合物结构 描述：Ac-VRHA-conh-[4-(4-丁基)-苯氧基-1-苯基-2-丁基]，作用靶点为菱形蛋白酶（Rhomboid protease）GlpG 作者：斯凯洛娃（Skerlova, J）、波洛文科金（Polovinkin, V）、巴赫（Bach, K）、博尔什切夫斯基（Borshchevskiy, V）、斯特里索夫斯基（Strisovsky, K） 提交日期：2022-07-04 发布日期：2023-10-25 最后修改日期：2026-03-04 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.4埃（2.4 Å） 引用文献：支化取代基对菱形蛋白酶酮酰胺抑制剂引物侧化学空间的广泛靶向可增强其选择性与活性。《欧洲药物化学杂志》（Eur. J. Med. Chem.），第275卷，2024年