Transcriptional effect of RZ-2994 vs. DMSO on T-cell acute lymphoblastic leukemia cell line
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https://www.ncbi.nlm.nih.gov/sra/SRP239561
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Purpose: Identify new therapeutic pathways for T-cell acute lymphoblastic leukemia (T-ALL) therapy. Methods: KOPTK1 cells were grown in the presence of 2µM RZ-2994 vs DMSO, and cells collected at 24 and 72 hours of treatment. Three samples were collected per treatment condition per time point. RNA was extracted from cells with an RNeasy Kit (Qiagen). Results: RZ-2994 treatment of T-ALL cell lines resulted in changes pathways affecting cell cycle control, amino acid metabolism and gene sets associated with MYC changes. Conclusions: Our study supports the therapeutic targeting of SHMT1 and SHMT2 in T-ALL. Overall design: KOPTK1 Tcell ALL cell lines treated with RZ-2994 and DMSO, in triplicate, for one day and for three days
创建时间：
2021-09-12
