ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo MARTX toxin, bound to ATP-Mg-actin, human profilin 1 and a sulfate ion

ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo MARTX toxin, bound to ATP-Mg-actin, human profilin 1 and a sulfate ion Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... Authors: Teixeira-Nunes, M, Renault, L, Retailleau, P. Deposit date: 2022-11-04 Release date: 2023-09-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.699 Å) Cite: Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin. Plos Pathog., 19, 2023

源自黑色弧菌（Vibrio nigripulchritudo）MARTX毒素的ExoY核苷酸环化酶结构域（ExoY Nucleotidyl Cyclase domain），与ATP-镁-肌动蛋白、人类前纤维蛋白1（human profilin 1）及硫酸根离子结合。描述物：2-氨基-2-羟甲基-1,3-丙二醇、腺苷-5'-三磷酸、肌动蛋白…… 作者：Teixeira-Nunes, M、Renault, L、Retailleau, P。存入日期：2022-11-04；发布日期：2023-09-20；最后修改日期：2023-10-04。实验方法：X射线衍射（1.699埃）。引用文献：《结合肌动蛋白-前纤维蛋白的细菌ExoY核苷酸环化酶毒素的多步激活与催化机制的功能与结构解析》，PLOS Pathogens，第19卷，2023年。