Comparison between nitroglycerine and vehicle treatments in mouse trigeminal ganglia and nucleus accumbens

Chronic nitroglycerin treatment elicits hyperalgesia in mice that is significantly augmented by a human migraine trigger and reduced with migraine therapy. The purpose of this study was to profile mRNA levels (transcriptome) to understand the differences between nitroglicerin and vehicle treatments in two nervous system regions, the trigeminal ganglia and the nucleus accumbens, Overall design: RNA samples were obtained from 10 mice 24 hours after the last nitroglicerin injection (Intraperitoneal injections of nitroglycerin every second day for 9 days total) and were subjected to paired-end RNA sequencing