Subcellular localization of tumor-associated PTEN mutations motif on a PTEN 1–403 background.

*Percentage of COS-7 cells showing nuclear (N), cytoplasmic (C), or nuclear/cytoplasmic staining (N/C) is indicated. Note that, in the context of PTEN wild type (wt) 1–403, most of the mutations displayed predominant cytoplasmic localization. The mutations L23F, M35R, and G36R favored PTEN 1–403 nuclear accumulation. Mutations are from COSMIC database (http://cancer.sanger.ac.uk/cosmic)Subcellular localization of tumor-associated PTEN mutations motif on a PTEN 1–403 background.