List of positions located in the 7-TMs of rhodopsin (Rho), beta-2 adrenergic receptor (β₂-AR) and adenosine receptor (A_2A) that are in contact with the co-crystallized ligand (underlined) and/or qualified as key positions (in bold and marked with an <b><i>X</i></b>).

The MI data refer to the analysis performed on the MSA of the 7-TMs class A receptors. The position has highest MI (among all other inter-TM positions) with the listed pair position (pp). Rank is the MI ranking of that pair using the class A 7-TM MSA (287 sequences) and the degree is calculated using MI graph from top 600 MI pairs. Positions not included in the MI graph have “n.a.” ascribed to the degree value. Entropy and MI are measured in bits.