Role of rs3129882 SNP in Monocyte Chromatin Accessibility Programs

The rs312889 SNP is located in the MHCII locus and conferrs susceptibility to Parkinson's Disease. As the disease associated allele is non-coding, we sought to test if it was linked to epigenetic changes within the MHCII locus or more broadly in antigen presenting cells. In this study, monocytes were purified from individuals with the AA protective or GG risk alleles that were diagnosed with Parkinsons's disease or healthy. Monocytes were stimulated with IFNg for 18 hours or allowed to rest and then subjected to ATAC-seq analysis. ATAC-seq of four-five replicates of each indicated sample.