Metadata record for the article: Interim Clinical Trial Analysis of Intraoperative Mass Spectrometry for Breast Cancer Surgery

Summary This metadata record provides details of the data supporting the claims of the related article: “Interim Clinical Trial Analysis of Intraoperative Mass Spectrometry for Breast Cancer Surgery”. The related study describes the ex vivo intraoperative clinical application of mass spectrometry (MS) using a liquid micro-junction surface sample probe (LMJ-SSP) to assess breast cancer margins. Type of data: lipidomics; mass spectrometry using a liquid micro-junction surface sample probe Subject of data: Homo sapiens Sample size: breast conserving surgery (BCS) specimens from 21 subjects Population characteristics: treatment naive females over 18 years of age, with invasive breast cancer who were breast conservation therapy candidates at presentation Recruitment: Participants were recruited at a clinic visit by their treating surgeon co-investigator. Eligible patients were introduced to the study by their care team and, if interested, met with a member of the research team for further discussion and screening. If agreeable to participate, the patient and surgeon went through the informed consent form together and sign where applicable. Trial registration number: NCT02335671 Data access The de-identified lipidomics data underlying Figures 2-5 in the related article are contained in the Excel spreadsheet ‘SI_Table_Breast_MassSpec_Aligned_TIC.xlsx’, which is shared publicly as part of this data record. A copy of the same data is also available as Supplementary Table 1 of the article. Corresponding author(s) for this study Nathalie Y. R. Agar, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115. [e-mail] Study approval Approved by Dana-Farber Cancer Institute IRB. Written informed consent was obtained from all subjects.