Capecitabine Action Pathway
收藏NIAID Data Ecosystem2026-03-10 收录
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https://www.ndexbio.org/viewer/networks/567de98e-2022-11e9-bb6a-0ac135e8bacf
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资源简介：
Capecitabine is a fluoropyrimidine anticancer drug. After absorption, it is metabolized in the liver to the intermediate 5’-deoxy-5-fluorouridine, which is subsequently converted into 5-fluorouracil (5-FU) by intracellular thymidine phosphorylase. 5-FU exerts cytotoxic effects on the cell by direct incorporation into DNA and RNA as well as by inhibiting thymidylate synthase. Since thymidine phosphorylase is present at 3-10 fold higher concentration in cancer cells compared normal cells, capecitabine’s cytotoxic effect is selective for cancer cells.
创建时间：
2019-02-01
