Transmission of homogenous GSS-102L prions to wild type FVB mice or transgenic mice expressing PrP 102L or wild type human PrP.
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IHC = immunohistochemistry; IB = immunoblotting. Tg35c and Tg152c are congenic on FVB/N genetic background. * Three IPD P102L patient brain isolates were passaged in 102LL Tg27 transgenic mice to generate GSS-102L prions. Details of these primary transmission are described in reference [33]. † All samples were analysed by both IB and IHC using monoclonal antibodies ICSM 18 and ICSM 35. In 102LL Tg27 tissues ICSM 35 serves as a control to define non-specific background. ‡ Positive either by clinical signs, immunoblotting and/or immunohistochemistry. # All samples were positive for ICSM 18 but negative for ICSM 35. § All samples were negative for both ICSM 18 and ICSM 35. Transmission of homogenous GSS-102L prions to wild type FVB mice or transgenic mice expressing PrP 102L or wild type human PrP.
