Crystal structure of the catalytic domain of MMP-12 in complex with a selective sugar-conjugated arylsulfonamide carboxylate water-soluble inhibitor (DC27).

Protein Data Bank Japan2024-01-10 更新2026-03-21 收录

下载链接：

https://pdbj.org/mine/summary/5i0l

下载链接

链接失效反馈

官方服务：

资源简介：

Crystal structure of the catalytic domain of MMP-12 in complex with a selective sugar-conjugated arylsulfonamide carboxylate water-soluble inhibitor (DC27). Descriptor: (2R)-2-[{(E)-2-[({(2R,3R,4R,5S,6R)-3-(acetylamino)-4,5-bis(acetyloxy)-6-[(acetyloxy)methyl]tetrahydro-2H-pyran-2-yl}carbamothioyl)amino]ethenyl}(biphenyl-4-ylsulfonyl)amino]-3-methylbutanoic acid, 1,2-ETHANEDIOL, CALCIUM ION, ... Authors: Stura, E.A, Rosalia, L, Cuffaro, D, Tepshi, L, Ciccone, L, Rossello, A. Deposit date: 2016-02-04 Release date: 2016-07-06 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Sugar-Based Arylsulfonamide Carboxylates as Selective and Water-Soluble Matrix Metalloproteinase-12 Inhibitors. Chemmedchem, 11, 2016

基质金属蛋白酶-12（Matrix Metalloproteinase-12）催化结构域与选择性糖缀合芳基磺酰胺羧酸类水溶性抑制剂（DC27）结合的晶体结构。描述符：(2R)-2-[(E)-2-[({(2R,3R,4R,5S,6R)-3-(乙酰氨基)-4,5-二(乙酰氧基)-6-[(乙酰氧基)甲基]四氢-2H-吡喃-2-基}硫代氨基甲酰)氨基]乙烯基](联苯-4-基磺酰)氨基]-3-甲基丁酸、1,2-乙二醇、钙离子…… 作者：Stura E.A.、Rosalia L.、Cuffaro D.、Tepshi L.、Ciccone L.、Rossello A. 沉积日期：2016-02-04 发布日期：2016-07-06 最后修改日期：2024-01-10 测试方法：X射线衍射（2.45埃）引用文献：《基于糖类的芳基磺酰胺羧酸类化合物作为选择性水溶性基质金属蛋白酶-12抑制剂》，Chemmedchem，第11卷，2016年

创建时间：

2016-02-04