Raw data for Kalathur et al., 2015 ‘The unfolded protein response and its potential role in Huntington ́s disease elucidated by a systems biology approach’

Data file 1. Legend: Lists of upregulated genes in 6 murine and 1 human (first sheet), and in at least 4 murine and 1 human HD model (second sheet).Data file 2. Lists of downregulated genes in 5 datasets (first sheet) and in at least 4 datasets (second sheet).Data file 3. Lists of upregulated UPR genes with stress response elements in the promoter regions (-1000bp to +500bp). Results for highly stringent gene list (UPR genes uprgulated in 6 murine and 1 human HD model) are show on sheet 1; results for less stringent gene list (upregulated in at least 4 murine and 1 human HD model) are displayed on sheet 2.Data file 4. List of all the biological processes that are enriched amongin differentially regulated UPR genes. Results for UPR gene list of high stringency are show on sheet 1; results for gene list of lower stringency are displayed on sheet 2.Data file 5. List of all the pathways that are enriched among upregulated UPR genes. Results for UPR gene list of high stringency are show on sheet 1; results for gene list of lower stringency are displayed on sheet 2.Data file 6. List of components of UPR interactome shown in Figure 6Data file 7. List of genes common between UPR and ApoptosisData file 8. List of proteins that interact with HTT directly or indirectly.Data file 9. List of 53 proteins that were found in the intersection of HTT interactors, HDTT and differentially regulated UPR genes (of lower stringeny). It includes the 13 proteins from table 3 that were identified using the high stringency list of differentially regulated UPR genes. Spearman correlation coefficients and the corresponding estimated fdr for correlation or anti correlation, respectively, describe the observed correlation of gene expression and the length of polyglutamine tract in HD mice.

数据文件1：图例：列出6个小鼠和1个人类上调基因（首张表格），以及至少4个小鼠和1个人类HD模型的上调基因（第二张表格）。数据文件2：列出5个数据集中的下调基因（首张表格）以及至少4个数据集中的下调基因（第二张表格）。数据文件3：列出在启动子区域（-1000bp至+500bp）具有应激反应元件的上调UPR基因列表。高度严格的基因列表（在6个小鼠和1个人类HD模型中上调的UPR基因）的结果显示在第一张表格中；较宽松的基因列表（在至少4个小鼠和1个人类HD模型中上调）的结果显示在第二张表格中。数据文件4：列出在差异调控UPR基因中富集的所有生物学过程。高度严格的UPR基因列表的结果显示在第一张表格中；较低严格度的基因列表的结果显示在第二张表格中。数据文件5：列出在上调UPR基因中富集的所有通路。高度严格的UPR基因列表的结果显示在第一张表格中；较低严格度的基因列表的结果显示在第二张表格中。数据文件6：列出图6中展示的UPR互作组的成分。数据文件7：列出UPR与细胞凋亡共有的基因列表。数据文件8：列出直接或间接与HTT相互作用的蛋白质列表。数据文件9：列出在HTT互作者、HDTT和差异调控的UPR基因（较低严格度）的交集发现的53种蛋白质。其中包括使用高度严格的差异调控UPR基因列表所确定的表3中的13种蛋白质。Spearman相关系数及其对应的关联或反关联的估计fdr分别描述了基因表达与HD小鼠多聚谷氨酰胺 tract长度的观察相关性。