Homo sapiens Raw sequence reads

Early diagnosis of colorectal cancer (CRC) and precancerous advanced adenoma (AA) is of vital importance. Previously we profiled small extracellular vesicles (sEVs) derived miRNAs isolated from plasma, proposed a new promising biomarker category of CRC. Here we further gave a full landscape of circulating sEVs derived RNAs, including miRNAs, mRNAs, and lncRNAs, to explore and evaluate sEVs based RNA biomarkers for early detection of both CRC and AA patients.