SOX4 promotes T cell acute lymphoblastic leukemia progression

We report a previously unrecognized role of SOX4 in T cell acute lymphoblastic leukemia (T-ALL). To explore SOX4-dependent gene regulation, RNA-seq analysis was conducted and the differently expressed genes were revealed in the SOX4-knockdown Jurkat cells in comparison to control group. mRNA profiles of Jurkat cells transfected with scramble shRNA (sh-Scb) or sh-SOX4 were generated by RNA sequencing, in double, using Illumina NovaSeq6000.