p53 cancer mutant Y220S in complex with small-molecule stabilizer PK9323
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p53 cancer mutant Y220S in complex with small-molecule stabilizer PK9323 Descriptor: 1-[9-ethyl-7-(1,3-thiazol-4-yl)carbazol-3-yl]-~{N}-methyl-methanamine, Cellular tumor antigen p53, GLYCEROL, ... Authors: Joerger, A.C, Kraemer, A, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2019-08-08 Release date: 2020-02-19 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm. Acs Chem.Biol., 15, 2020
与小分子稳定剂PK9323结合的p53癌症突变体Y220S 描述项：1-[9-乙基-7-(1,3-噻唑-4-基)咔唑-3-基]-N-甲基甲胺、细胞肿瘤抗原p53、甘油…… 作者：Joerger, A.C、Kraemer, A、Knapp, S、结构基因组联盟（Structural Genomics Consortium, SGC） 提交日期：2019-08-08 发布日期：2020-02-19 最后修改日期：2024-01-24 实验方法：X射线衍射（分辨率1.8 Å） 引用文献：《通过小分子稳定剂靶向造腔型p53癌症突变体：Y220X范式》，ACS Chem.Biol.，15卷，2020年
