Inhibition of DHODH Activates Pyroptosis and cGAS-STING Pathways to Enhance NK cell Infiltration Mediated Anti-tumor Immunity in Melanoma

Our research indicated that inhibition of DHODH activates pyroptosis and cGAS-STING pathways to enhance NK cell infiltration. And the tumor-infiltrating NK cells facilitate melanoma cells pyroptosis which providing a positive feedback mechanism for DHODH-mediated anti-tumor immunity.
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本研究表明，DHODH的抑制可激活焦亡和cGAS-STING通路，以增强自然杀伤细胞（NK细胞）的浸润。肿瘤浸润的NK细胞促进黑色素瘤细胞的焦亡，从而为DHODH介导的抗肿瘤免疫提供正反馈机制。以下数据为我们的研究原始数据，其中关键资源亦在此数据中展示。