Structure of neuronal nitric oxide synthase D597N/M336V mutant heme domain in complex with 6-{{(3'R,4'R)-3'-[2"-(3'''-fluorophenethylamino)ethoxy]pyrrolidin-4'-yl}methyl}-4-methylpyridin-2-amine

Structure of neuronal nitric oxide synthase D597N/M336V mutant heme domain in complex with 6-{{(3'R,4'R)-3'-[2"-(3'''-fluorophenethylamino)ethoxy]pyrrolidin-4'-yl}methyl}-4-methylpyridin-2-amine Descriptor: 1,2-ETHANEDIOL, 5,6,7,8-TETRAHYDROBIOPTERIN, 6-{[(3R,4R)-4-(2-{[2-(3-fluorophenyl)ethyl]amino}ethoxy)pyrrolidin-3-yl]methyl}-4-methylpyridin-2-amine, ... Authors: Li, H, Delker, S.L, Poulos, T.L. Deposit date: 2010-06-21 Release date: 2010-11-03 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives. J.Med.Chem., 53, 2010

神经元型一氧化氮合酶（neuronal nitric oxide synthase）D597N/M336V突变体血红素结构域与6-{(3'R,4'R)-3'-[2''-(3'''-氟苯乙氨基)乙氧基]吡咯烷-4'-基}甲基}-4-甲基吡啶-2-胺形成复合物的晶体结构。描述项：1,2-乙二醇、5,6,7,8-四氢生物蝶呤、6-{[(3R,4R)-4-(2-{[2-(3-氟苯基)乙基]氨基}乙氧基)吡咯烷-3-基]甲基}-4-甲基吡啶-2-胺等。作者：Li, H、Delker, S.L、Poulos, T.L.。提交日期：2010-06-21；发布日期：2010-11-03；最后修改日期：2023-09-06。实验方法：X射线衍射（分辨率2.15埃）。引用文献：《通过设计合成吡咯烷甲基2-氨基吡啶衍生物探索神经元型一氧化氮合酶的活性位点》，J.Med.Chem., 53, 2010