Spike protein gets N-glycosylated

Glycosyltransferases in the endoplasmatic reticulum are responsible for the attachment of numerous high-mannose N-glycans on the SARS-CoV-2 spike protein. After virion assembly and release these glycosidations are required for fusion with host cells (Watanabe et al, 2020, Breuer et al, 2001).<br><br>O-glycosylations do occur on the Spike protein with an average overall frequency per site of less than 50 percent (Sanda et al, 2020).

内质网中的糖基转移酶负责将众多高甘露糖 N-糖苷连接到 SARS-CoV-2 突刺蛋白上。在病毒颗粒组装和释放之后，这些糖基化过程对于与宿主细胞融合至关重要（Watanabe 等，2020年，Breuer 等，2001年）。此外，在突刺蛋白上亦存在 O-糖基化，平均每个位点的总发生率低于 50%（Sanda 等，2020年）。