Synthesis and Biological Evaluation of Himanimide C and Unnatural Analogues

Recently isolated himanimide C (1) can be prepared via a short, flexible, and stereoselective synthesis using a copper-mediated tandem
vicinal difunctionalization of dimethyl acetylenedicarboxylate (DMAD, 8) as a key step. The flexibility of the synthesis is exemplified by the
preparation of new unnatural himanimide analogues in order to investigate the fungicidal potency of this new family.