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Synthesis and Biological Evaluation of Himanimide C and Unnatural Analogues

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NIAID Data Ecosystem2026-03-06 收录
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Recently isolated himanimide C (1) can be prepared via a short, flexible, and stereoselective synthesis using a copper-mediated tandem vicinal difunctionalization of dimethyl acetylenedicarboxylate (DMAD, 8) as a key step. The flexibility of the synthesis is exemplified by the preparation of new unnatural himanimide analogues in order to investigate the fungicidal potency of this new family.

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2016-05-06
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