Data from: Developmental polychlorinated biphenyl (PCB) exposure impacts on voiding physiology persist into adulthood and influence sensitivity to bladder stimuli in mice

Polychlorinated biphenyls (PCBs) are toxicants present in the environment
and are linked to numerous adverse health effects; however, impacts of
developmental PCB exposure on lower urinary tract function are
understudied. We have previously found developmental exposure (in utero
and lactational) to a human-relevant PCB mixture in mice leads to sex- and
dose- dependent changes to urinary voiding physiology at 6 weeks of age.
This study expands upon previous findings to investigate if developmental
PCB-induced urinary voiding phenotypes persist or shift as mice age to 12
weeks of age. Urinary voiding physiology testing through void spot assays,
uroflowmetry, and cystometry demonstrated several sex- and dose- dependent
effects of PCB exposure at 12 weeks of age. This study demonstrates
developmental exposure to PCBs continues to impact lower urinary tract
function in adulthood to at least 12 weeks of age both during homeostatic
conditions and upon challenge of capsaicin in mice. Better understanding
of how early life stressors like PCBs contribute to aging-associated
voiding dysfunction are imperative as these findings may help mitigate
risk or improve treatment strategies for patients suffering from lower
urinary tract symptoms. This dataset provides the raw data for
mouse void spot assays, uroflowmetry, cystometry and tissue mass endpoints
for manuscript: "Developmental Polychlorinated Biphenyl (PCB)
Exposure Impacts on Voiding Physiology Persist into Adulthood and
Influence Sensitivity to Bladder Stimuli in Mice". The data is
provided in an excel speadsheet and each tab of the spreadsheet represents
the raw data from each endpoint assessed including void spot assay,
uroflowmetry, cystometry, cystometry with capsaicin, and tissue and body
mass. These data correspond to each figure in the manuscript. The data are
organized by PCB treatment group and littermates are entered into
subcolumns within each treatment group to allow for nesting of the data to
account for litter effects.