Dose-response of cancer cell lines.

The spreadsheet contains the following results/datasets according to the sheet name. Between Cell line Dose Responses: mean difference comparison of the dose-responses to pathway inhibitors between the cancer cell lines that have a higher dependence on dark and light genes and those with a lower dependence on dark and light genes as defined using the CRISPR-derived gene dependence scores (see methods section). Mutations Gene Drug Response: mean dose-response comparison between cell lines that have a mutation(s) in a particular gene versus those that do not have a mutation(s) in that particular gene. Pathways: List of pathways from which our analyses are based. Pathway Inhibitors: List of pathway inhibitors from which our analyses are based. The rest of the sheets contain drug sensitive and resistant genes for all 24 pathways (e.g., PI3K MTOR), PI3K MTOR CRISPR: genes that are associated with significantly increased sensitivity to different pathway inhibitors in cell lines demonstrating higher dependence on the specific gene(s) for their fitness. And genes that are associated with a significant resistance to different pathway inhibitors in cell lines demonstrating higher dependence on the specific gene(s) for their fitness. PI3K MTOR Mutation: genes that are associated with significantly increased sensitivity to different pathway inhibitors in cell lines that have mutations in the specific gene. And genes that are associated with significant resistance to different pathway inhibitors in cell lines that have mutations in the specific gene. (XLSX)