Transcriptomic analysis of RNA-sequencing data from nontransgenic and transgenic tau SPAM mice

We performed RNA-sequencing of nontransgenic and transgenic By line of tau SPAM mice (expressing the S320F/P301S aggregating mutations) at different ages of 2, 4, and 6 months. All of the samples were obtained from brain cortex. Comparison of differentially expressed genes between nontransgenic mice and transgenic tau SPAM mice at different ages of 2, 4, and 6 months. Differential expression analysis was focused on aged tau SPAM mice and nontransgenic mice of 6 months.