TP53 loss initiates chromosomal instability in fallopian tube epithelial cells
收藏NIAID Data Ecosystem2026-03-13 收录
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资源简介：
High-grade serous ovarian cancer originates in the fallopian tube and is characterized by ubiquitous mutations in TP53. Here, we generated TP53 single-, TP53/BRCA1 and TP53/MYC double- and TP53/BRCA1/MYC triple-mutant subclones of the fallopian tube-derived cell line FNE1 using CRISPR/Cas9. These mutant subclones were subsequently subjected to RNA sequencing to determine the impact of these oncogenic mutations on signaling pathways. RNA sequencing of 27 fallopian tube-derived cell lines.
创建时间：
2021-12-15
