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Direct Observation of Structural Dynamics in the Dimerization of DNA Base Pai...

B2FIND2026-03-19 收录

DNA损伤机制

光二聚化动力学

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https://b2find.eudat.eu/dataset/92dad702-debd-50c0-a898-fccefe378541 数据链接链接失效反馈

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The UV-induced formation of lesions in DNA has intrigued scientists since its first observation in 1958. Thymine (T), cytosine (C), and uracil (U) undergo photodimerization upon...

应用场景：

白血病靶向治疗

DNA损伤机制

Histone deacetylase inhibitors (HDACi) are promising anti-cancer agents, however, their mechanisms of action remain unclear. In acute myeloid leukemia (AML) cells, HDACi have been reported to arrest g

NIAID Data Ecosystem70

Enol Tautomers of Watson−Crick Base Pair Models Are Metastable Because of Nuclear Quantum Effects

分子动力学模拟

DNA损伤机制

Intermolecular enol tautomers of Watson−Crick base pairs could emerge spontaneously via interbase double proton transfer. It has been hypothesized that their formation could be facilitated by thermal

NIAID Data Ecosystem50

Data_Sheet_4_WIP1 Contributes to the Adaptation of Fanconi Anemia Cells to DNA Damage as Determined by the Regulatory Network of the Fanconi Anemia and Checkpoint Recovery Pathways.pdf

范可尼贫血通路

DNA损伤机制

DNA damage adaptation (DDA) allows the division of cells with unrepaired DNA damage. DNA repair deficient cells might take advantage of DDA to survive. The Fanconi anemia (FA) pathway repairs DNA inte

NIAID Data Ecosystem20

Whole genome sequencing of RPE1 LATS1/2-double knockout cells implanted into mice.

小鼠疾病模型

DNA损伤机制

To demonstrate in vivo that DNA damage is induced in YAP-activated cells by weight-bearing activities, we performed whole genome DNA sequencing of RPE1 LATS1/2-double knockout cells were simultaneousl

NIAID Data Ecosystem70

Table_11_Reduction of H3K27cr Modification During DNA Damage in Colon Cancer.xlsx

组蛋白巴豆酰化

DNA损伤机制

DNA damage plays an essential role in the initiation and development of colon cancer. Histone crotonylation is a newly discovered post-translational modification that is thought to promote gene expres

NIAID Data Ecosystem40

Direct Observation of Structural Dynamics in the Dimerization of DNA Base Pai...

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