Additional file 2 of Charting the future: current and future directions in translational research for individuals with Down syndrome

Supplementary Material 2: Table 2: Clinical studies of Down syndrome. A total of 362 studies were exported from ClinicalTrials.gov that match search criteria for the Condition/Disease “DS” or Other Term “T21” in August 2024. Of those 362 studies, 25 have the term “biomarker” listed anywhere in a Data Field and 101 have an outcome measure directly related to the brain. Age group of DS study participants among study subsets were labeled as “Prenatal” if one of the following terms occurred in a Data Field then manually curated to confirm relevance: “prenatal, pregnant, pregnancy, fetus, fetal, and maternal.” Tab 1 contains all studies and Tab 2 contains a subset of those that have an outcome measure directly related to the brain. Tab 2 was manually curated to confirm correct output of “Intervention” Study Type. Please note that the study sponsor or investigator is responsible for the safety, science, and accuracy of any information submitted to ClinicalTrials.gov ( https://clinicaltrials.gov/about-site/disclaimer ).