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Next Generation Sequencing Facilitates Quantitative Analysis of the effects of TNFa treatment on sorted mouse lung ILC2 Transcriptomes

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE133672
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TNFa induces secretion of ILC2 effector cytokines ex vivo. Increased ILC2 activation leads to the development of airway hyperreactiviy and lung inflammation. Targeting TNFa may therefore represent a novel therapeutic target to treat asthma. mRNA profiles of sorted mouse lung ILC2s treated either with PBS or TNFa were generated by deep sequencing, in triplicate, using a NextSeq 500 (Illumina) system.
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2021-07-01
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