Additional file 2 of Association of plasma proteomics with mortality in individuals with and without type 2 diabetes: Results from two population-based KORA cohort studies

Additional file 2: Table S1. Longitudinal association of single protein biomarkers with all-cause mortality among participants with and without type 2 diabetes in the KORA S4 sample (233 proteins); Table S2. Validation of results in KORA-Age1 for proteins significantly associated with all-cause mortality in the KORA S4 sample; Table S3. Associations of 35 validated proteins of all-cause mortality in the group with type 2 diabetes with cause-specific mortality in the pooled sample ( n = 447); Table S4. Associations of 62 validated proteins of all-cause mortality in the group without type 2 diabetes with cause-specific mortality in the pooled sample ( n = 2129); Table S5. 68 validated proteins for all-cause mortality and their association with cause-specific mortality and interaction effect with type 2 diabetes in the pooled sample; Table S6. Sensitivity analysis for all-cause and cause-specific mortality after exclusion of overlapping KORA S4 participants from the KORA-Age1 sample among participants with type 2 diabetes in the pooled sample ( n = 402); Table S7. Sensitivity analysis for all-cause and cause-specific mortality after exclusion of overlapping KORA S4 participants from the KORA-Age1 sample among participants without type 2 diabetes in the pooled sample ( n = 1943); Table S8. Sensitivity analysis considering other causes of death as competing risk among participants with type 2 diabetes in the pooled sample; Table S9. Sensitivity analysis considering other causes of death as competing risk among participants without type 2 diabetes in the pooled sample; Table S10. Proteins tested by other measurements in the KORA S4 sample; Table S11. Top pathways related to all-cause, cardiovascular, cancer-related and other-cause mortality enriched by their associated protein biomarkers; Table S12. Predictive performance for all-cause mortality after exclusion of overlapping KORA S4 participants from the KORA-Age1 sample; Table S13. Overlap of 68 mortality-related protein biomarkers identified in the present analysis with previous literature.