Human GKRP bound to AMG-2668

Human GKRP bound to AMG-2668 Descriptor: 5-{[(3S)-3-(prop-1-yn-1-yl)-4-{4-[S-(trifluoromethyl)sulfonimidoyl]phenyl}piperazin-1-yl]sulfonyl}pyridin-2-amine, D-SORBITOL-6-PHOSPHATE, GLYCEROL, ... Authors: Jordan, S.R, Chmait, S. Deposit date: 2014-01-17 Release date: 2014-07-30 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.58 Å) Cite: Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series. J.Med.Chem., 57, 2014结合AMG-2668的人源葡糖激酶调节蛋白（glucokinase regulatory protein, GKRP） 描述项：5-{[(3S)-3-(丙-1-炔基)-4-{4-[S-(三氟甲基)磺酰亚胺基]苯基}哌嗪-1-基]磺酰基}吡啶-2-胺、D-山梨醇-6-磷酸、甘油…… 作者：S.R. Jordan、S. Chmait 提交日期：2014-01-17 发布日期：2014-07-30 最后修改日期：2023-09-20 实验方法：X射线衍射（2.58埃） 引用文献：葡糖激酶-葡糖激酶调节蛋白相互作用的小分子破坏剂：3. N-芳基磺酰胺基-N'-芳基哌嗪系列芳基甲醇区域的构效关系. J.Med.Chem., 57, 2014