Total Synthesis of Cryptophycin Analogues via a Scaffold Approach

Allylation of in situ generated β,γ-unsaturated aldehydes affords rapid access to vinyl halide analogues of fragment A of the cryptophycins.
Three scaffolds are prepared in gram quantities by a ring-closing metathesis approach. Derivatization via a variety of cross-coupling protocols
is possible, which affords novel analogues of these potent antimitotic agents.