Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1
收藏NIAID Data Ecosystem2026-03-10 收录
数据链接：
官方服务：
资源简介：
The dCTP pyrophosphatase 1 (dCTPase) is involved in the regulation of the cellular dNTP pool and has been linked to cancer progression. Here we report on the discovery of a series of 3,6-disubstituted triazolothiadiazoles as potent dCTPase inhibitors. Compounds 16 and 18 display good correlation between enzymatic inhibition and target engagement, together with efficacy in a cellular synergy model, deeming them as a promising starting point for hit-to-lead development.
创建时间：
2017-02-15
