Transcriptome study of colon epithelial cells in Reg3a-transgenic mice
收藏NIAID Data Ecosystem2026-03-11 收录
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资源简介：
The human C-type lectin Reg3a (HIP/PAP) is an antimicrobial peptide that kills Gram-positive bacteria. Reg3a preserves gut microbiota homeostasis, reinforces intestinal barrier function and thereby helps to fight induced colitis in mice. Transcriptomic data revealed an upregulation of numerous genes involved in the robustness of the intestinal barrier, and the biosynthesis pathway of mucin core 1 and 3 O-glycans. Transcriptome analysis was performed on colon sections from wild-type and Reg3a-transgenic C57BL/6N mice non-treated or treated with 3% dextran sodium sulfate using GeneChip® Mouse Gene 1.0 ST arrays (Affymetrix).
创建时间：
2019-03-04
