Crystal structure of the TYK2 pseudokinase domain in complex with compound 8

Crystal structure of the TYK2 pseudokinase domain in complex with compound 8 Descriptor: (8S)-N-cyclopropyl-5-[(2-methoxypyridin-3-yl)amino]-7-(methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide, Non-receptor tyrosine-protein kinase TYK2 Authors: Toms, A.V, Leit, S, Greenwood, J.R, Carriero, S, Mondal, S, Abel, R, Ashwell, M, Blanchette, H, Boyles, N, Cartwright, M, Collis, A, Feng, S, Ghanakota, P, Harriman, G.C, Hosagrahara, V, Kaila, N, Kapeller, R, Rafi, S, Romero, D.L, Tarantino, P, Timaniya, J, Wester, R.T, Westlin, W, Srivastava, B, Miao, W, Tummino, P, McElwee, J.J, Edmondson, S.D, Massee, C.E. Deposit date: 2023-03-27 Release date: 2023-07-26 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279. J.Med.Chem., 66, 2023本数据集为与化合物8结合的TYK2假激酶结构域晶体结构。配体描述：(8S)-N-环丙基-5-[(2-甲氧基吡啶-3-基)氨基]-7-(甲氨基)吡唑并[1,5-a]嘧啶-3-甲酰胺；靶标：非受体酪氨酸蛋白激酶TYK2。作者：Toms, A.V, Leit, S, Greenwood, J.R, Carriero, S, Mondal, S, Abel, R, Ashwell, M, Blanchette, H, Boyles, N, Cartwright, M, Collis, A, Feng, S, Ghanakota, P, Harriman, G.C, Hosagrahara, V, Kaila, N, Kapeller, R, Rafi, S, Romero, D.L, Tarantino, P, Timaniya, J, Wester, R.T, Westlin, W, Srivastava, B, Miao, W, Tummino, P, McElwee, J.J, Edmondson, S.D, Massee, C.E. 存档日期：2023-03-27；发布日期：2023-07-26；最后修改日期：2024-10-09。实验方法：X射线衍射（分辨率1.87 Å）。引用文献：Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279. J.Med.Chem., 66, 2023