Crystal structure of PPAR gamma (PPARG) in complex with JP85 (compound 1).

Crystal structure of PPAR gamma (PPARG) in complex with JP85 (compound 1). Descriptor: 2-[4-chloranyl-6-(5,6,7,8-tetrahydronaphthalen-1-ylamino)pyrimidin-2-yl]sulfanylethanoic acid, GLYCEROL, Peroxisome proliferator-activated receptor gamma Authors: Chaikuad, A, Pollinger, J, Merk, D, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2022-08-24 Release date: 2023-07-12 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPAR gamma Modulation. J.Am.Chem.Soc., 145, 2023

PPARγ（PPARG）与JP85（化合物1）结合的晶体结构。描述信息：2-[4-氯-6-(5,6,7,8-四氢萘-1-基氨基)嘧啶-2-基硫基]乙酸、甘油、过氧化物酶体增殖物激活受体γ。作者：Chaikuad, A、Pollinger, J、Merk, D、Knapp, S、结构基因组学联盟（Structural Genomics Consortium, SGC）。提交日期：2022-08-24；发布日期：2023-07-12；最后修改日期：2024-02-07。实验方法：X射线衍射（分辨率1.9 Å）。引用文献：《靶向替代维生素E代谢物结合位点实现非经典PPARγ调控》，《美国化学会志》，145卷，2023年。