Global Proteomic Analysis of E-cadherin Function in Mouse Embryonic Stem Cells Using iTRAQ and LC-MS/MS

This project identifies all the proteomic changes that take place in mouse embryonic stem cells after the knockout of the cell-cell adhesion protein E-cadherin. It identifies several putative pathways and sheds the light on the role of E-cadherin in controlling metabolsim of these pluripotent stem cells. The downregulation of E-cadherin resulted in the inhibiton of mitochondrial complex III and the upregulation of HIF-alpha-1 targets