Discovery of Efficient Hypoxia-Targeted NO Donor Compounds to Alleviate Hypoxia Cardiac Disease

In
order to obtain efficient NO donor drugs to treat hypoxic cardiac
disease, a series of hypoxia-targeted NO donor compounds were prepared
and screened. Among them, a representative compound H3 was found to selectively release NO under hypoxia with a higher
ratio than isosorbide dinitrate (ISDN). In vitro study indicated that H3 had a strong capability of alleviating vascular dilation
and reducing myocardial hypoxic injury due to its effective regulation
of vascular dilatation and myocardial injury-related proteins in H9c2
cells even at low concentrations. By intraperitoneal injection or
intragastric administration, in vivo animal tests revealed that H3 possessed a potent antimyocardial hypoxic injury effect
superior to ISDN. These findings suggest that H3 has
a better effect on alleviating hypoxic cardiac disease than the conventional
drug, owing to its hypoxia-targeted release of NO.