Crystal structure of the cAMP-dependent protein kinase A cocrystallized with 1,7-Naphthyridin-8-amine and PKI (5-24)

Crystal structure of the cAMP-dependent protein kinase A cocrystallized with 1,7-Naphthyridin-8-amine and PKI (5-24) Descriptor: 1,7-naphthyridin-8-amine, DIMETHYL SULFOXIDE, cAMP-dependent protein kinase catalytic subunit alpha, ... Authors: Oebbeke, M, Heine, A, Klebe, G. Deposit date: 2020-02-17 Release date: 2020-09-30 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Fragment based drug design - Small chemical changes of fragments effecting big changes in binding To Be Published与1,7-萘啶-8-胺（1,7-Naphthyridin-8-amine）和PKI(5-24)共结晶的环腺苷酸依赖型蛋白激酶A（cAMP-dependent protein kinase A）的晶体结构 描述项：1,7-萘啶-8-胺、二甲基亚砜（DIMETHYL SULFOXIDE）、α亚型环腺苷酸依赖型蛋白激酶催化亚基（cAMP-dependent protein kinase catalytic subunit alpha）…… 作者：Oebbeke, M、Heine, A、Klebe, G 沉积日期：2020-02-17 发布日期：2020-09-30 最后修改日期：2024-11-20 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.01埃 引用文献：基于片段的药物设计——片段的细微化学变化可引发结合特性的显著改变（待发表）