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Uncovering the dosage-dependent roles of Arid1a in gastric tumorigenesis for combinatorial drug therapy. Uncovering the dosage-dependent roles of Arid1a in gastric tumorigenesis for combinatorial drug therapy

NIAID Data Ecosystem2026-04-25 收录

肿瘤发生机制

组合治疗

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA603539 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

应用场景：

创建时间：

2020-01-28

肿瘤发生机制

Wnt信号通路调控

Bcl9 and Pygo function within the Wnt enhanceosome to effect β-catenin-dependent transcription. Whether they also mediate β-catenin-dependent neoplasia is unclear. Here we assess their roles in intest

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Transcriptome changes following loss of Apc in the intestine. Mus musculus

肿瘤发生机制

Wnt信号通路靶基因

Nearly all colorectal cancers have dysregulated Wnt signalling, predominantly through the mutation of the Apc (Adenomatous Polyposis Coli) gene. Therefore it is of vital importance to elucidate the ke

NIAID Data Ecosystem10

OncoSig: a new algorithm for the accurate and systematic de novo prediction of Oncoprotein-centric Signaling networks. OncoSig: a new algorithm for the accurate and systematic de novo prediction of Oncoprotein-centric Signaling networks

癌症信号网络

肿瘤发生机制

We introduce a new algorithm, OncoSig, to address the deficiencies of canonical pathways through the accurate, context-specific prediction of proteins representing both known and novel functional memb

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SOCS2 expression correlates with tumor malignancy, exerts growth promoting effects and is enhanced by androgens in prostate cancer

癌症生物标志物

肿瘤发生机制

Deregulation of cytokine- and growth factor signaling due to altered expression of endogenous regulators is well recognized in prostate and other cancers. Suppressor of cytokine signaling 2 (SOCS2) is

NIAID Data Ecosystem20

MYC binding to the E-box in the 5-UTR of Nle1 predisposes mice to intestinal tumors

肿瘤发生机制

MYC调控机制

Nle1 encodes a WD40 repeats-containing protein highly conserved in eukaryotes and involved in Notch signaling pathway. Previous studies have shown that inhibition/loss-of-function of NLE1 alleviates d

NIAID Data Ecosystem10

Uncovering the dosage-dependent roles of Arid1a in gastric tumorigenesis for combinatorial drug therapy. Uncovering the dosage-dependent roles of Arid1a in gastric tumorigenesis for combinatorial drug therapy

资源简介：

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