Synthesis of Functionalized 6‑Hydroxy-2-oxindole Derivatives by Phenoxide Cyclization
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An apparent intramolecular cross-dehydrogenative coupling of N-(3-hydroxy)monoanilide of maleic esters comprising base promoted phenoxide cyclization and subsequent base-mediated aerobic oxidation was developed to synthesize a variety of 2-(6-hydroxy-2-oxoindolin-3-ylidene)acetate derivatives. The isolation of intermediate cyclized products during the large scale reactions and their ready dehydrogenation with 1 equiv of base support this proposed two-step path.
创建时间：
2016-11-23
