the anti lipid accumulation and anti liver cancer formation effect of CACF in CD36 overexpression transgenic zebrafish

Carassius auratus complex formula (CACF) is composed of extracts from Carassius auratus, Rhizoma dioscoreae, Lycium chinense, and Rehmannia glutinosa Libosch. These ingredients are used to treat diabetes since ancient China. Previously, CACF elicits antidiabetic effects in streptozotocin-induced diabetic mouse models under high-fat diet treatment, reduces triglyceride levels, maintains blood sugar control, and enhances insulin sensitivity. However, the effects of CACF on anti-cancer and anti-inflammation and the underlying mechanism remain unknown. In this study, we revealed that CACF could be a promising therapeutic agent with multiple functions Comparative gene expression profiling analysis of RNA-seq data for CD36 zebrafish treat with or without CACF and use CD36 normal diet as control