Genome-wide analysis of long noncoding RNA expression profile in spontaneously hypertensive rat treated by Ganoderma lingzhi oligopeptide

Angiotensin I-converting enzyme (ACE) plays a vital role in cardiovascular disease (CVD). Natural ACE inhibitory peptides from Ganoderma lingzhi (G. lingzhi) showed potential vasodilatation in vitro or in vivo. Recent studies have shown that long non-coding (lncRNA) plays critical roles in biological processes and human diseases, since the roles of lncRNA in CVD remain unclear. Our findings indicate that the expression profiles of lncRNAs has changed in spontaneously hypertensive rats (SHRs) treated by the G. lingzhi peptide, compared with untreatedt groups. It is expected to provide novel insight into the underlying molecular mechanism and potential targets for hypertention therapy. Microarray expression profiling of mRNAs and lncRNAs were conducted using RNA extracted from three SHR thoracic aorta samples administrated by G. lingzhi peptide and three untreated samples.