The combination therapy enhanced suppression of tumor growth and metastasis in a rodent model of HCC.

NOTE: Intrahepatic tumors, lung and lymph node metastasis, bloody ascites, as well as peritoneal seeding in rats were evaluated on day 38 following orthotopic implantation of MH tumor fragments. Treatment with either vehicle or indicated drug (n = 9 per group) started on day 10 after tumor implantation. Tumor sizes were presented by both volume in cubicmillimeters and weight in grams (mean ± SE). Lung and lymph node metastasis, as well as peritoneal seeding, were denoted as the visually positive tumor nodules (the percentages were indicated in parentheses).*Pt test (versus combination group).#P