Schistosomula exposed to HDAC inhibitor (Trichostatin A) [12hrs]

HDACs inhibitors induces mortality in the parasite Schistosoma mansoni (schistosomula and adult worms), and became an interesting drug class for the development of new drugs to treat schistosomiasis. In order to understand the effect of histone hyperacetylation on the parasite, we tested the effect of the HDAC inhibitor Trichostatin A on schistosomula gene expression. Newly transformed schistosomula were exposed to 1 µM Trichostatin A or vehicle solution (ethanol) and kept in culture for 12 h. Three independent biological replicates were assayed for each condition.