Acinetobacter baumannii DNA gyrase B 23kDa ATPase subdomain complexed with EBL2704

Acinetobacter baumannii DNA gyrase B 23kDa ATPase subdomain complexed with EBL2704 Descriptor: 2-[[3,4-bis(chloranyl)-5-methyl-1H-pyrrol-2-yl]carbonylamino]-4-[(1R)-1-phenylethoxy]-1,3-benzothiazole-6-carboxylic acid, 2-[[3,4-bis(chloranyl)-5-methyl-1H-pyrrol-2-yl]carbonylamino]-4-[(1S)-1-phenylethoxy]-1,3-benzothiazole-6-carboxylic acid, DNA gyrase subunit B Authors: Cotman, A.E, Zega, A, Zidar, N, Ilas, J, Tomasic, T, Masic, L.P, Mundy, J.E.A, Stevenson, C.E.M, Burton, N, Lawson, D.M, Maxwell, A, Kikelj, D. Deposit date: 2021-09-17 Release date: 2022-09-28 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa. J.Med.Chem., 66, 2023鲍曼不动杆菌（Acinetobacter baumannii）DNA旋转酶（DNA gyrase）B亚基23kDa ATP酶结构域（ATPase subdomain）与EBL2704的复合物。描述：2-[[3,4-二氯-5-甲基-1H-吡咯-2-基]甲酰胺基]-4-[(1R)-1-苯乙氧基]-1,3-苯并噻唑-6-羧酸、2-[[3,4-二氯-5-甲基-1H-吡咯-2-基]甲酰胺基]-4-[(1S)-1-苯乙氧基]-1,3-苯并噻唑-6-羧酸。作者：Cotman, A.E、Zega, A、Zidar, N、Ilas, J、Tomasic, T、Masic, L.P、Mundy, J.E.A、Stevenson, C.E.M、Burton, N、Lawson, D.M、Maxwell, A、Kikelj, D。保藏日期：2021-09-17；发布日期：2022-09-28；最近修改日期：2024-02-07。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.6埃（Å）。引用文献：《苯并噻唑骨架类DNA旋转酶抑制剂的发现及命中化合物到先导化合物的优化：对鲍曼不动杆菌与铜绿假单胞菌具有强效活性》，《J.Med.Chem.》，2023年，第66卷