Critical ACE2 Determinants of SARS-CoV-2 and Group 2B Coronavirus Infection and Replication
收藏DataCite Commons2022-12-21 更新2025-04-16 收录
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https://www.immport.org/shared/study/SDY1868
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资源简介：
Through molecular modeling and empirical in vitro validation, the study identified 5 key amino acid differences between murine and human ACE2 that mediate SARS-CoV-2 infection, generating a chimeric humanized murine ACE2. Additionally, the study examined the ability of the generated humanized murine ACE2 receptor to permit infection by an additional preemergent group 2B coronavirus, WIV-1, providing evidence for the potential pan-virus capabilities of this chimeric receptor.
提供机构：
ImmPort
创建时间：
2021-10-11
