Critical ACE2 Determinants of SARS-CoV-2 and Group 2B Coronavirus Infection and Replication
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Through molecular modeling and empirical in vitro validation, the study identified 5 key amino acid differences between murine and human ACE2 that mediate SARS-CoV-2 infection, generating a chimeric humanized murine ACE2. Additionally, the study examined the ability of the generated humanized murine ACE2 receptor to permit infection by an additional preemergent group 2B coronavirus, WIV-1, providing evidence for the potential pan-virus capabilities of this chimeric receptor.
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ImmPort创建时间：
2021-10-11
