The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells [array]

ChEBI2015-04-29 更新2026-07-21 收录

免疫细胞分化

Th17/Treg平衡调控

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The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells [array]

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2015-04-29

SMAD4 impedes conversion of NK cells into ILC1-like cells by curtailing non-canonical TGFb signaling (mouse data sets). Mus musculus

免疫细胞分化

TGFb信号通路

Among the features that distinguish type 1 innate lymphoid cells (ILC1s) from NK cells is a gene signature indicative of TGFb-family cytokine imprinting. To assess the impact of TGFb family cytokines

NIAID Data Ecosystem70

Additional file 7 of Single-cell transcriptomics highlights immunological dysregulations of monocytes in the pathobiology of COPD

单细胞转录组学

免疫细胞分化

Additional file 7: Dataset 5. Genes dynamically expressed during CD14+ classical monocyte-to-CD14+ intermediate monocyte differentiation, related to Fig. S3M and S3N, in which the top 250 genes based

Figshare2022-12-20 更新40

Histone architecture of stem-cell memory T cells reveals progressive remodeling of epigenetic landscape in antigen-experienced CD8 T cells. Mus musculus

细胞表观遗传学

免疫细胞分化

We investigated the genomic landscape of histone modifications in antigen-experienced CD8+ T cells. Using a ChIP-Seq approach coupled with global gene expression profiling [GSE67825], we generated gen

NIAID Data Ecosystem20

Dynamic redistribution of CTCF demarcates bifurcation of cytotoxic effector and memory precursor programs [RNA-Seq]

免疫细胞分化

表观遗传调控

CTCF is known to mediate long range chromatin intearction and 3D genome organization. In CD8+ T cells responding to actue infection, CTCF is redistributed to induce the the cytotoxic program while usi

NIAID Data Ecosystem50

Mitochondria-lysosome crosstalk dictates the progressive differentiation of Treg cells to limit inflammation-associated immunopathology [ATAC-seq2]

免疫细胞分化

染色质可及性分析

Chromatin profiling in WT and Opa1-deficient Treg cells. Overall design: CD45.2+CD45.1-CD4+Foxp3-YFP+ Treg cells were sorted from WT mixed BM chimera (n = 4) and Foxp3CreOpa1fl/fl mixed BM chimera (n

NIAID Data Ecosystem20

The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells [array]

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