Identification of BiP as a temperature sensor mediating temperature-induced germline sex reversal

The temperature sensor transduces temperature into a germline sex-governing signal, while the transition of genotypic germline sex determination (GGSD) and temperature-dependent germline sex determination (TGSD) remain mysterious. We identify thermosensitive BiP as a conserved temperature sensor in TGSD and provide mechanistic insights for transition of GGSD and TGSD.