Crystal structure of homodimeric R132H mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP
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Crystal structure of homodimeric R132H mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP Descriptor: Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Yang, B, Peng, Y, Ding, J. Deposit date: 2010-03-24 Release date: 2010-11-10 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (3.41 Å) Cite: Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H. Cell Res., 20, 2010
人类胞质NADP(+)依赖性异柠檬酸脱氢酶同源二聚体R132H突变体与NADP结合的晶体结构 描述项:异柠檬酸脱氢酶[NADP] 胞质型,NADP(烟酰胺腺嘌呤二核苷酸磷酸) 作者:Yang B、Peng Y、Ding J 入库日期:2010年3月24日 发布日期:2010年11月10日 最后修改日期:2023年11月1日 实验方法:X射线衍射(分辨率3.41埃) 引用文献:肿瘤相关突变R132H介导的人类IDH1(异柠檬酸脱氢酶1)活性“开关式”调控分子机制,《细胞研究》(Cell Res.),20卷,2010年




