Crystal Structure of the first bromodomain of human BRD4 L94C variant in complex with racemic 3,5-dimethylisoxazol ligand

Crystal Structure of the first bromodomain of human BRD4 L94C variant in complex with racemic 3,5-dimethylisoxazol ligand Descriptor: 3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[(~{R})-oxidanyl(pyridin-3-yl)methyl]phenol, 3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[(~{S})-oxidanyl(pyridin-3-yl)methyl]phenol, Bromodomain-containing protein 4 Authors: Thomas, A.M, McDonough, M.A, Schiedel, M, Conway, S.J. Deposit date: 2023-02-15 Release date: 2023-08-02 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Mutate and Conjugate: A Method to Enable Rapid In-Cell Target Validation. Acs Chem.Biol., 18, 2023人类BRD4首个溴结构域（bromodomain）L94C变体与外消旋3,5-二甲基异恶唑配体复合物的晶体结构 描述：3-(3,5-二甲基-1,2-恶唑-4-基)-5-[(R)-羟基(吡啶-3-基)甲基]苯酚、3-(3,5-二甲基-1,2-恶唑-4-基)-5-[(S)-羟基(吡啶-3-基)甲基]苯酚 含溴结构域蛋白4（Bromodomain-containing protein 4） 作者：Thomas, A.M.、McDonough, M.A.、Schiedel, M.、Conway, S.J. 提交日期：2023-02-15 发布日期：2023-08-02 最后修改日期：2023-11-29 实验方法：X射线衍射（分辨率1.88 Å） 引用文献：Mutate and Conjugate: A Method to Enable Rapid In-Cell Target Validation. 《ACS化学生物学》（ACS Chem. Biol.）, 18, 2023